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Showing 1–3 of 3 results
Advanced filters: Author: Shay A. Toner Clear advanced filters

  • U.S. select agent regulations ignore easily assembled DNA fragments, making synthesis screening ineffective regardless of accuracy. We acquired unregulated DNA collectively sufficient for a skilled individual to generate 1918 influenza from dozens of providers, demonstrating that fragments must be regulated as select agents.

    • Rey Edison
    • Shay Toner
    • Kevin M. Esvelt
    Comments & OpinionOpen Access
    Nature Communications
    P: 1-5

  • Michita et al. show that Zika virus (ZIKV) NS1 induces tunneling nanotubes (TNTs) in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. Infection with a NS1 mutant ZIKV not inducing TNTs results in a higher interferon response than wild-type ZIKV infection.

    • Rafael T. Michita
    • Long B. Tran
    • Anoop Narayanan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The development of new drugs to treat COVID-19 continues to be of critical importance. This paper describes a new in-cell assay to screen for inhibitors of SARSCoV-2 in live cells. 8 new compounds are reported along with a crystal structure of a key viral protease, Mpro, in complex with one of the newly discovered compounds.

    • Anoop Narayanan
    • Manju Narwal
    • Joyce Jose
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17