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Showing 1–11 of 11 results
Advanced filters: Author: Shee-Mei Lok Clear advanced filters

  • The 3.7 Å cryo-electron microscopy structure of Zika virus is presented, revealing a typical flavivirus architecture; in contrast to the related flavivirus dengue virus, Zika virus is thermally stable at 40 °C, and this structural stability may be a feature that helps it to survive in semen, saliva and urine.

    • Victor A. Kostyuchenko
    • Elisa X. Y. Lim
    • Shee-Mei Lok
    Research
    Nature
    Volume: 533, P: 425-428

  • The structure of flavivirus surface proteins has been elucidated, but the conformation of capsid proteins within particles is less clear. Here, the authors provide a subnanometer resolution structure of Zika virus capsid protein within the virus particle, elucidating its quaternary organization and role in flavivirus packaging.

    • Ter Yong Tan
    • Guntur Fibriansah
    • Shee-Mei Lok
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.

    • Seamus R. Morrone
    • Valerie S. Y. Chew
    • Shee-Mei Lok
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • An antibody to dengue virus that lies flat on its target, neutralizes the virus and also prevents antibody-dependent enhancement of infection is now identified.

    • Shee-Mei Lok
    News & Views
    Nature Immunology
    Volume: 19, P: 1150-1152

  • There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections.

    • Shuijun Zhang
    • Victor A. Kostyuchenko
    • Shee-Mei Lok
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).

    • Xin-Xiang Lim
    • Arun Chandramohan
    • Ganesh S. Anand
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13