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Nature Metabolism (2)

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Advanced filters: Author: Shelagh M. Fluharty Clear advanced filters

Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress

Korobkina et al. show that ACLY in brown fat prevents metabolic overload in the tricarboxylic acid cycle, thus ensuring adequate thermogenesis by avoiding cellular stress.

Ekaterina D. Korobkina
Camila Martinez Calejman
David A. Guertin
Research14 Oct 2024
Nature Metabolism

Volume: 6, P: 2187-2202
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis

In this study, Park, Haley, Le, Jung et al. perform a detailed characterization in vivo of metabolic flux distribution during thermogenesis and uncover brown fat nutrient fluxes and unexpected inter-organ metabolic crosstalk and glutamine utilization.

Grace Park
John A. Haley
David A. Guertin
Research19 Jun 2023
Nature Metabolism

Volume: 5, P: 1204-1220

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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis

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