Using T-jump 2D-IR spectroscopy, Zhang et al. show that DNA minor-groove binder Hoechst 33258 strongly destabilizes its complex with DNA (H-DNA). This study suggests that the association of H-DNA is a concerted process, where Hoechst 33258 cooperates with DNA single strands in forming H-DNA.
- Xin-Xing Zhang
- Shelby L. Brantley
- Andrei Tokmakoff
