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Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes

Following myocardial infarction, patients are at risk for reperfusion-induced ventricular fibrillation, a life-threatening condition. Here, Liang et al. show that the known ventricular fibrillation preventive effects of carbon monoxide are mediated through the inhibition of a subset of inward-rectifying potassium channels.

Shenghui Liang
Quanyi Wang
Yuchun Gu
Research14 Aug 2014
Nature Communications

Volume: 5, P: 1-7
Convergent somatic evolution commences in utero in a germline ribosomopathy

Shwachman-Diamond Syndrome (SDS) is an inherited ribosome assembly disorder that increases the risk for haematopoietic malignancies. Here, the authors analysed clonal selection and evolution in SDS by sequencing patient-derived haematopoietic stem/progenitor cell colonies and exploring the function of key drivers in model organisms.

Heather E. Machado
Nina F. Øbro
Alan J. Warren
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-14
Somatic genetic rescue of a germline ribosome assembly defect

Shwachman-Diamond syndrome (SDS) is a leukemia predisposition disorder that is caused by defective release of eIF6 during ribosome assembly. Here the authors show that acquired somatic EIF6 mutations are frequent in the hematopoietic cells from individuals with SDS and provide a selective advantage over non-modified cells.

Shengjiang Tan
Laëtitia Kermasson
Patrick Revy
ResearchOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1-17
Publisher Correction: Somatic genetic rescue of a germline ribosome assembly defect

Shengjiang Tan
Laëtitia Kermasson
Patrick Revy
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Nonreciprocal terahertz beam steering based on magneto-optic metagratings

Zhiyu Tan
Fei Fan
Shengjiang Chang
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
eIF6 rebinding dynamically couples ribosome maturation and translation

Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.

Pekka Jaako
Alexandre Faille
Alan J. Warren
ResearchOpen Access23 Mar 2022
Nature Communications

Volume: 13, P: 1-11
Vesicle miR-195 derived from Endothelial Cells Inhibits Expression of Serotonin Transporter in Vessel Smooth Muscle Cells

Junzhong Gu
Huiyuan Zhang
Yuchun Gu
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-10

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Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes

Convergent somatic evolution commences in utero in a germline ribosomopathy

Somatic genetic rescue of a germline ribosome assembly defect

Publisher Correction: Somatic genetic rescue of a germline ribosome assembly defect

Nonreciprocal terahertz beam steering based on magneto-optic metagratings

eIF6 rebinding dynamically couples ribosome maturation and translation

Vesicle miR-195 derived from Endothelial Cells Inhibits Expression of Serotonin Transporter in Vessel Smooth Muscle Cells

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