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ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

Enolase 1 (ENO1) is a critical glycolytic enzyme that plays essential roles in pathological activities. Here, Sun, Suo, Zhang, Shen et al. reveal the nonmetabolic function of ENO1 in liver cancer, where ENO1 promotes YAP1 mRNA translation to activate arachidonic acid metabolism thus promoting cancer growth.

Linchong Sun
Caixia Suo
Ping Gao
Research27 Jul 2023
Nature Chemical Biology

Volume: 19, P: 1492-1503
Citrullination modulation stabilizes HIF-1α to promote tumour progression

Post-translational modifications on HIF-1α can regulate its stability and activity in tumoral processes. Here, the authors show that PADI4-mediated citrullination avoids HIF-1α degradation to promote hepatocellular carcinoma progression and this can be prevented by a PADI4 antagonist

Rui Chen
Zhiyuan Lin
Ping Gao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Correction: Author Correction: Menin enhances c-Myc-mediated transcription to promote cancer progression

Gongwei Wu
Mengqiu Yuan
Ping Gao
Amendments and CorrectionsOpen Access30 Mar 2018
Nature Communications

Volume: 9, P: 1
Selective radical-type perfluoro-tert-butylation of unsaturated compounds with a stable and scalable reagent

Despite the promising potential of the perfluoro-tert-butyl (PFtB) group in diverse fields, incorporating PFtB into organic molecules remains challenging. Here, the authors describe a stable and scalable reagent for radical-type perfluoro-tert-butylation, which is synthesized in large scale from commercial perfluoro-tert-butanol and a designed benzothiazole hypervalent iodonium salt.

Ruitong Zhang
Shengqi Zhou
Chao Chen
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-10
CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

Phosphorylation catalyzed by kinases is a key event in signaling pathways involved in cardiomyocyte hypertrophy. Here the authors show that the kinase CLK4 ameliorates cardiac hypertrophy by phosphorylating NEXN.

Jian Huang
Luxin Wang
Yi-Han Chen
ResearchOpen Access30 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance

The MBD2c splicing variant of MBD2 that is essential for nuclear transcription translocates to the mitochondria to regulate mitochondrial DNA transcription and respiration and is linked to drug resistance in cancer cells.

Yijie Hao
Zilong Zhou
Huafeng Zhang
Research28 Nov 2024
Nature Chemical Biology

Volume: 21, P: 926-938
HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression

Aberrant expression of the human hexokinase HKDC1 has been observed in patients with cancer. Here the authors report that HKDC1 expression is associated with hepatocellular carcinoma progression and PD-L1 mediated immune evasion.

Yi Zhang
Mingjie Wang
Ping Gao
ResearchOpen Access13 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

Carnosine is a mobile buffering metabolite. Here the authors link carnosine accumulation, hypoxia and intracellular pH homeostasis in cancer cells as a mechanism of tumor immune evasion via NFX1 degradation and galectin-9 activity.

Ronghui Yan
Pinggen Zhang
Ping Gao
Research04 Jan 2024
Nature Immunology

Volume: 25, P: 483-495
Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8⁺ T-cell exhaustion

Itaconate is an immunomodulatory metabolite that has been reported to regulate tumorigenesis. Here, the authors show that macrophage-derived itaconate induces epigenetic-mediated CD8⁺ T cell exhaustion, promoting hepatocellular carcinoma development.

Xuemei Gu
Haoran Wei
Ping Gao
ResearchOpen Access09 Dec 2023
Nature Communications

Volume: 14, P: 1-15
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

Zhang and colleagues report a function of the glycolytic enzyme α-Enolase 1 in iron homeostasis. In this setting it promotes the mRNA decay of IRP1, thereby suppressing ferroptosis in hepatocellular carcinoma.

Tong Zhang
Linchong Sun
Huafeng Zhang
Research09 Dec 2021
Nature Cancer

Volume: 3, P: 75-89
Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps

The secretome of hepatocytes and hepatocellular carcinoma (HCC) cells can contribute to cancer progression. Here the authors show that PRSS35 inhibits HCC progression through proteolytic depletion of CXCL2 and subsequently decreased neutrophil recruitment to tumours.

Ting Wang
Yingli Zhou
Huafeng Zhang
ResearchOpen Access18 Mar 2023
Nature Communications

Volume: 14, P: 1-16
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

Shi-Ting Li
De Huang
Ping Gao
Research16 Mar 2020
Nature Metabolism

Volume: 2, P: 256-269
Menin enhances c-Myc-mediated transcription to promote cancer progression

Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.

Gongwei Wu
Mengqiu Yuan
Ping Gao
ResearchOpen Access05 May 2017
Nature Communications

Volume: 8, P: 1-15
Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis

Neng Wang
Yifeng Zheng
Zhiyu Wang
ResearchOpen Access06 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy

A universal strategy to realize anisotropy-free dispersive components, such as arrayed waveguide gratings, on a uniaxial in-plane anisotropic thin-film lithium niobate platform is introduced for the first time.

Junjie Yi
Changjian Guo
Liu Liu
ResearchOpen Access29 Jun 2024
Light: Science & Applications

Volume: 13, P: 1-11
Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase

Yinghui Wang
Hui Lu
Ping Gao
ResearchOpen Access02 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-13
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Linchong Sun
Libing Song
Huafeng Zhang
Research20 Mar 2015
Cell Research

Volume: 25, P: 429-444

Search

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Correction: Author Correction: Menin enhances c-Myc-mediated transcription to promote cancer progression

Selective radical-type perfluoro-tert-butylation of unsaturated compounds with a stable and scalable reagent

CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation

Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance

HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression

Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8⁺ T-cell exhaustion

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Menin enhances c-Myc-mediated transcription to promote cancer progression

Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis

Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

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