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Advanced filters: Author: Shenyou Nie Clear advanced filters

  • PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

    • Lu Wang
    • Xiao-Yong Xie
    • Guo-Jun Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17