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Showing 1–2 of 2 results
Advanced filters: Author: Sherimay Ablan Clear advanced filters

  • HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain and SP1 region bound to BVM.

    • Sucharita Sarkar
    • Kaneil K. Zadrozny
    • Tatyana Polenova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.

    • Mingzhang Wang
    • Caitlin M. Quinn
    • Tatyana Polenova
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12