To address the inherent hydrophobic and bioinert natures of synthetic polymeric membranes, we design and construct bioinspired and osteopromotive polydopamine nanoparticle-incorporated fibrous membranes through co-electrospinning of polycaprolactone (PCL) with polydopamine nanoparticles (PDA NPs). The multifunctional membranes are demonstrated to possess prominent cytocompatibility and osteo-differentiation potential of human mesenchymal stem cells (hMSCs) without any growth factors, as well as boosted bone regeneration in vivo using a mouse calvarial critical-sized defect. Accordingly, such engineered PDA/PCL fibrous membranes, which are osteoinductive and easy to transplant, have great potential for guided tissue regeneration application.
- Yi Deng
- Wei-Zhong Yang
- Shi-Cheng Wei
