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Showing 1–3 of 3 results
Advanced filters: Author: Shi-Mao Xia Clear advanced filters

  • Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.

    • Rory Henderson
    • Brian E. Watts
    • S. Munir Alam
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • Jinsong Zhang
    • Laurent Verkoczy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-20

  • Longitudinal sampling is used to map the evolution of an HIV-1 virus from the time of infection, and the co-evolution of a broadly neutralizing antibody in the same infected patient; the findings have important implications for HIV vaccine development.

    • Hua-Xin Liao
    • Rebecca Lynch
    • Barton F. Haynes
    Research
    Nature
    Volume: 496, P: 469-476