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Showing 1–4 of 4 results
Advanced filters: Author: Shibiao Wan Clear advanced filters

  • Super-enhancers are regions of genomic DNA comprised of multiple putative enhancers that contribute to dynamic gene expression patterns during development. Here the authors identify a modular super-enhancer in murine retinal development and show that distinct modules are responsible for retinal progenitor cell proliferation during early and bipolar neuron genesis during late retinal development.

    • Victoria Honnell
    • Jackie L. Norrie
    • Michael A. Dyer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, their links with tumor progression and evolution, and their potential as therapeutic targets.

    • Yanling Liu
    • Jonathon Klein
    • Xiaotu Ma
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Splicing dysfunction has been observed in Alzheimer’s disease but it remains unclear whether splicing defects have a causal role. Here the authors generate a mouse model with perturbed U1 snRNP activity, recapitulating RNA splicing defects, neuron hyperexcitability, neurodegeneration and synergy with the amyloid cascade when crossed with 5xFAD mice.

    • Ping-Chung Chen
    • Xian Han
    • Junmin Peng
    Research
    Nature Aging
    Volume: 2, P: 923-940

  • Mature cardiac muscle requires high mitochondrial ATP production and specialized contractile proteins. Here the authors demonstrate that cardiomyocyte-specific contractile maturation involves cooperation between the nuclear receptor ERRγ and cardiogenic transcription factor GATA4, but ERRγ controls metabolic genes independently.

    • Tomoya Sakamoto
    • Kirill Batmanov
    • Daniel P. Kelly
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20