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Showing 1–2 of 2 results
Advanced filters: Author: Shifra Klein Clear advanced filters

  • Physiological effects of psychological stress and infection in mothers can increase the incidence of anxiety and psychiatric diseases in offsprings and in subsequent generation. Here, Miklos Toth and colleagues show that intergenerational inheritance of neurological traits is propagated across multiple generations independently by parallel non-genetic mechanisms involving independent segregation of epigenetic specific loci.

    • Emma Mitchell
    • Shifra L. Klein
    • Miklos Toth
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • The authors show, in mice, that maternal tumor necrosis factor-α (TNFα) genotype affects postnatal phenotypes in adult offspring. Lack of either one or two copies of the Tnf gene in dams led to reduced levels of chemokines in their milk, increased levels of adult hippocampal neurogenesis and improved spatial memory in offspring.

    • Bingfang Liu
    • Bojana Zupan
    • Miklos Toth
    Research
    Nature Neuroscience
    Volume: 17, P: 97-105