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Showing 1–4 of 4 results
Advanced filters: Author: Shijiao Huang Clear advanced filters

  • Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-6, and the inhibition of Cdc6 on Sas-6 is negatively regulated by Plk4 phosphorylation.

    • Xiaowei Xu
    • Shijiao Huang
    • Chuanmao Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.

    • Hillary A. Miller
    • Shijiao Huang
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress resistance and slow aging in C. elegans.

    • Hyo Sub Choi
    • Ajay Bhat
    • Scott F. Leiser
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Beydoun, Choi et al. develop a metabolically inactive food source for C. elegans worms that minimizes the confounding effects of bacterial metabolism on worm metabolism and aging. They find that worms eat and grow well on a paraformaldehyde (PFA)-treated E. coli food source, recommending the use of 0.5% PFA-killed bacteria as a nematode food source for metabolic experiments.

    • Safa Beydoun
    • Hyo Sub Choi
    • Scott F. Leiser
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9