Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restores the function and regeneration capacity of aged muscle.
- Nika Rajabian
- Izuagie Ikhapoh
- Stelios T. Andreadis
