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Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.

Weam S. Shahin
Shima O. Ebed
John F. Engelhardt
ResearchOpen Access27 Jan 2023
Nature Communications

Volume: 14, P: 1-13

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Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

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