The relationships between the physical parameters of β–cyclodextrin-based nanoparticles (CDNPs), the behavior of α-mangostin release, and the anticancer efficacy were revealed in this study. It was found that the lifetime of complex (τ2) in slow-release mode was linearly dependent on the nanoparticle density and showed a relationship with anticancer efficacy. We assumed that MGS released from CDNPs would accumulate in the tumor region if the optimal range of τ2 was approximately 90 to 140 h. These results suggest τ2 can be a critical quality attribute for designing our CDNPs.
- Van Thi Hong Doan
- Jun Katsuki
- Kazuo Sakurai
