Nature Search

Quantifying carbon stock and tree community composition in tropical forests through combining satellite and UAV analyses

Kotaro Komatsu
Ryuichi Takeshige
Ryota Aoyagi
ResearchOpen Access23 Jan 2026
Scientific Reports

P: 1-10
Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area

Hanyue Cecilia Lei
Kyle E. Parker
Shin-ichiro Imai
ResearchOpen Access16 Sept 2025
Molecular Psychiatry

P: 1-11
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Isolates of authentic SARS-CoV-2 variants BA.1 and BA.2 exhibit similar infectivity and pathogenicity and show susceptibility to neutralizing therapeutic antibodies and antiviral compounds in mouse and hamster models.

Ryuta Uraki
Maki Kiso
Yoshihiro Kawaoka
Research16 May 2022
Nature

Volume: 607, P: 119-127
Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter

Alessia Grozio
Kathryn F. Mills
Shin-ichiro Imai
Amendments and Corrections12 Jul 2019
Nature Metabolism

Volume: 1, P: 743
Identification of SARS-CoV-2 M^pro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.

Nobuyo Higashi-Kuwata
Kohei Tsuji
Hiroaki Mitsuya
ResearchOpen Access25 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD⁺ biosynthesis and thermogenesis in mice

Kiyoshi Yoshioka
Takumi Sugimoto
Shin-ichiro Imai
ResearchOpen Access24 Nov 2025
npj Aging

Volume: 11, P: 1-8
Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Alessia Grozio
Kathryn Mills
Shin-ichiro Imai
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 662-665
Consistent patterns of common species across tropical tree communities

Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

Declan L. M. Cooper
Simon L. Lewis
Stanford Zent
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 728-734
The brain, sirtuins, and ageing

Sirtuins and the neuron–microglia network have a key role in the ageing process. In this Review article, Satoh and colleagues discuss the role of sirtuins in age-related changes in communication between peripheral tissues and the brain, which has a key influence on ageing and longevity in mammals.

Akiko Satoh
Shin-ichiro Imai
Leonard Guarente
Reviews18 May 2017
Nature Reviews Neuroscience

Volume: 18, P: 362-374
Structure of Nampt/PBEF/visfatin, a mammalian NAD⁺ biosynthetic enzyme

Tao Wang
Xiangbin Zhang
Cynthia Wolberger
Research18 Jun 2006
Nature Structural & Molecular Biology

Volume: 13, P: 661-662
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin-ichiro Imai
Christopher M. Armstrong
Leonard Guarente
Research17 Feb 2000
Nature

Volume: 403, P: 795-800
Quantification of localized NAD⁺ changes reveals unique specificity of NAD⁺ regulation in the hypothalamus

Sean Johnson
Kiyoshi Yoshioka
Shin-ichiro Imai
ResearchOpen Access25 Jan 2023
npj Aging

Volume: 9, P: 1-9
Slc12a8 is a nicotinamide mononucleotide transporter

Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD⁺, but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD⁺ levels in vitro and in the mouse intestine in vivo.

Alessia Grozio
Kathryn F. Mills
Shin-ichiro Imai
Research07 Jan 2019
Nature Metabolism

Volume: 1, P: 47-57
Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides

Kenji Usui
Makoto Ozaki
Fumihiro Kayamori
ResearchOpen Access25 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

When used in CAR-T cell processing, the plant alkaloid berbamine prolongs the survival of leukemic animals by boosting CAR-T cell viability, memory phenotype, and persistence by modulating cellular metabolism, including mitochondrial respiration.

Shin-ichiro Takayanagi
Sayaka Chuganji
Shin Kaneko
ResearchOpen Access04 Jun 2024
Communications Biology

Volume: 7, P: 1-14
Anti-reflective coatings prepared via layer-by-layer assembly of mesoporous silica nanoparticles and polyelectrolytes

Anti-reflective coating films were fabricated via the layer-by-layer assembly of mesoporous silica nanoparticles and cationic polyelectrolytes. The thickness and packing density of coating films can be controlled by layer number and concentration of mesoporous silica nanoparticle dispersion to obtain excellent anti-reflective performance.

Kiyofumi Katagiri
Shin-ichiro Yamazaki
Kunihito Koumoto
Research19 Nov 2014
Polymer Journal

Volume: 47, P: 190-194
Systemic regulation of mammalian ageing and longevity by brain sirtuins

Sirtuins have been implicated in the ageing process in a variety of organisms, but their role in mammalian ageing remains somewhat controversial. Here the authors discuss sirtuin proteins in the brain, providing an overview of their physiological functions as well as their implication in mammalian ageing.

Akiko Satoh
Shin-ichiro Imai
Reviews26 Jun 2014
Nature Communications

Volume: 5, P: 1-11
Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)

Junya Unno
Kathryn F. Mills
Shin-ichiro Imai
ResearchOpen Access02 Jan 2024
npj Aging

Volume: 10, P: 1-12
Message from the new Co-Editor-in-Chief

Shin-ichiro Imai
EditorialOpen Access15 Feb 2017
npj Aging and Mechanisms of Disease

Volume: 3, P: 1
Impact of single dose of pegfilgrastim on peripheral blood stem cell harvest in patients with multiple myeloma or malignant lymphoma

Hideki Goto
Masashi Sawa
Takanori Teshima
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
It takes two to tango: NAD⁺ and sirtuins in aging/longevity control

Shin-ichiro Imai
Leonard Guarente
ReviewsOpen Access18 Aug 2016
npj Aging and Mechanisms of Disease

Volume: 2, P: 1-6
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

Shin-ichiro Imai
ReviewsOpen Access27 Jan 2025
npj Aging

Volume: 11, P: 1-12
Autonomic versus perceptual accounts for tactile hypersensitivity in autism spectrum disorder

Hiroshi Fukuyama
Shin-ichiro Kumagaya
Masaharu Kato
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis

Nozomi Imai
Tatsuo Hashimoto
Satoshi Umemura
Research18 Dec 2006
Laboratory Investigation

Volume: 87, P: 189-198
The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD⁺/SIRT1 in mammalian aging and longevity control

Shin-ichiro Imai
ReviewsOpen Access18 Aug 2016
npj Systems Biology and Applications

Volume: 2, P: 1-9

Search

Quantifying carbon stock and tree community composition in tropical forests through combining satellite and UAV analyses

Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter

Identification of SARS-CoV-2 M^pro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD⁺ biosynthesis and thermogenesis in mice

Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Consistent patterns of common species across tropical tree communities

The brain, sirtuins, and ageing

Structure of Nampt/PBEF/visfatin, a mammalian NAD⁺ biosynthetic enzyme

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Quantification of localized NAD⁺ changes reveals unique specificity of NAD⁺ regulation in the hypothalamus

Slc12a8 is a nicotinamide mononucleotide transporter

Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides

Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Anti-reflective coatings prepared via layer-by-layer assembly of mesoporous silica nanoparticles and polyelectrolytes

Systemic regulation of mammalian ageing and longevity by brain sirtuins

Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)

Message from the new Co-Editor-in-Chief

Impact of single dose of pegfilgrastim on peripheral blood stem cell harvest in patients with multiple myeloma or malignant lymphoma

It takes two to tango: NAD⁺ and sirtuins in aging/longevity control

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

Autonomic versus perceptual accounts for tactile hypersensitivity in autism spectrum disorder

Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD⁺/SIRT1 in mammalian aging and longevity control

Search

Quick links

Search

Filter By:

Search

Quick links