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Showing 1–3 of 3 results
Advanced filters: Author: Shireen A. Sarraf Clear advanced filters

  • The PINK1 ubiquitin kinase is shown to recruit the two autophagy receptors NDP52 and OPTN to mitochondria to activate mitophagy directly, independently of the ubiquitin ligase parkin; once recruited to mitochondria, NDP52 and OPTN recruit autophagy initiation components, and parkin may amplify the phospho-ubiquitin signal generated by PINK1, resulting in robust autophagy induction.

    • Michael Lazarou
    • Danielle A. Sliter
    • Richard J. Youle
    Research
    Nature
    Volume: 524, P: 309-314

  • The National Institute of Neurological Disorders and Stroke (NINDS) held an open workshop on April 23 and 24, 2024 to evaluate the gap between the current understanding of Parkinson’s disease (PD) and the development of therapeutics for treating PD. Representatives from key stakeholder groups discussed strategies for leveraging research to bridge this gap. Sessions focused on PD heterogeneity, target validation, development of tools and resources to facilitate therapeutics development, biomarker discovery and use, similarities and differences with PD-adjacent neurodegenerative diseases, and best practices for accelerating the therapeutics development process. Here are some of the main takeaways from the workshop.

    • Neel T. Dhruv
    • Sarah Robinson Schwartz
    • Amir P. Tamiz
    News & ViewsOpen Access
    npj Parkinson's Disease
    Volume: 11, P: 1-6