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Showing 1–3 of 3 results
Advanced filters: Author: Shirin Geravandi Clear advanced filters

  • Viruses such as coxsackievirus B (CVB) have been associated with type I diabetes (T1D) and islet destruction. Here the authors show that Yes-associated protein (YAP) is upregulated in the whole pancreas in T1D and at-risk autoantibody (AAb + ) organ donors and that YAP over-expression enhances CVB replication, islet inflammation and β-cell apoptosis and suggest exocrine-islet-immune interactions as targeted interventions for T1D.

    • Shirin Geravandi
    • Huan Liu
    • Amin Ardestani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26

  • Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

    • Ting Yuan
    • Karthika Annamalai
    • Amin Ardestani
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.

    • Amin Ardestani
    • Sijia Li
    • Kathrin Maedler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17