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Showing 1–2 of 2 results
Advanced filters: Author: Shirley H. Lomeli Clear advanced filters

  • Genomic analyses in a rapid autopsy cohort study of patients with melanoma identify the genetic and transcriptomic landscape of melanoma with acquired resistance to MAPK inhibitor and immune checkpoint blockade therapies, providing insights for the potential improvement of therapeutic strategies.

    • Sixue Liu
    • Prashanthi Dharanipragada
    • Roger S. Lo
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1123-1134

  • CRISPR-CATCH is used to isolate extrachromosomal DNA (ecDNA) molecules containing oncogenes from human cancer cells. CRISPR-CATCH followed by nanopore sequencing allows for methylation profiling, highlighting differences from the native chromosomal loci.

    • King L. Hung
    • Jens Luebeck
    • Howard Y. Chang
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1746-1754