Dysfunction of microglia in lipid processing after myelin phagocytosis contributes to the impaired remyelination in progressive multiple sclerosis. Here, the authors link depletion of neuregulin-1 in chronic demyelinated lesions to microglia foaminess that can be reversed therapeutically to promote remyelination in mice.
- Seyyed Mohyeddin Ziaee
- Shiva Nemati
- Soheila Karimi-Abdolrezaee
