The MARTX toxin of V. choleraeprocesses itself to deliver three distinct effector domains to the cytosol. Here the authors show that the third effector domain is a phosphatidylinositol-3-phosphate (PtdIns3P)-specific phospholipase that inhibits autophagy in target cells.
- Shivani Agarwal
- Hyunjin Kim
- Karla J. F. Satchell