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Showing 1–10 of 10 results
Advanced filters: Author: Shixian Lv Clear advanced filters
  • It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

    • Qiufen Sun
    • Liyun Zhao
    • Chan Qu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Non-nucleotide stimulators of interferon gene (STING) agonists hold great promise as the immunotherapeutic agents for cancer therapy. Here, this group reports incorporating STING agonist MSA-2 and DOX in the separate layers of 3D-printed polymeric scaffold for effectively activating STING-IFNβ pathway, enhancing DAMPs release thereby suppressing postsurgical tumor recurrence and metastasis.

    • Kai Li
    • Xuan Yu
    • Mingqiang Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26
  • Limitations in performance and stability of organic electrochemical transistors hinder their application in biosignal amplification. Here, the authors show that high-spin, hydrophilic conjugated polymers exhibit ambipolar charge transport properties and can capture and amplify diverse electrophysiological signals.

    • Gao-Yang Ge
    • Jingcao Xu
    • Ting Lei
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

    • Pek Kei Im
    • Neil Wright
    • Xiaoyi Zhang
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1476-1486
  • Dual-responsive disassembly of core-shell nanoplatform (Au@MPN) is reported with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy. Both ATP and low pH can disassemble the Au@MPN to release Fe(III), which can then be reduced into Fe(II) by the simultaneously released tannic acid. In particular, the exposed gold nanoparticles can catalyze the oxidation of intracellular glucose to produce H2O2. Subsequently, Fe(II) and the self-supplied H2O2 induce an efficient Fenton reaction for chemodynamic therapy by generating hydroxyl radicals. Additionally, tumor growth and melanoma metastatic lung cancer can be effectively suppressed by Au@MPN.

    • Mengran Peng
    • Enguo Ju
    • Mingqiang Li
    ResearchOpen Access
    NPG Asia Materials
    Volume: 14, P: 1-13