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Showing 1–3 of 3 results
Advanced filters: Author: Shoaib Mufti Clear advanced filters

  •  A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. 

    • Zizhen Yao
    • Cindy T. J. van Velthoven
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 624, P: 317-332

  • The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

    • Mariano I. Gabitto
    • Kyle J. Travaglini
    • Ed S. Lein
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2366-2383

  • The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) is a multifaceted open-data resource that is designed to identify cellular and molecular pathologies that underlie Alzheimer’s disease. Integrating neuropathology, single-cell and spatial genomics, and longitudinal clinical metadata, SEA-AD is a unique resource for studying the pathogenesis of Alzheimer’s disease and related dementias.

    • Michael Hawrylycz
    • Eitan S. Kaplan
    • Ed S. Lein
    Comments & Opinion
    Nature Aging
    Volume: 4, P: 1331-1334