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Showing 1–7 of 7 results
Advanced filters: Author: Shoh Asano Clear advanced filters

  • Pharmacological targeting of de novo lipogenesis is an attractive clinical target for a wide range of diseases. Kelly et al. report that de novo lipogenesis is essential for platelet production in primates, but not in dogs and rats.

    • Kenneth L. Kelly
    • William J. Reagan
    • William P. Esler
    Research
    Nature Metabolism
    Volume: 2, P: 1163-1178

  • ExFISH extends expansion microscopy to single-molecule RNA imaging, enabling super-resolution imaging of diverse RNAs in cells and tissues on conventional microscopes. The method enables multiplexed imaging of RNA and improved RNA quantitation.

    • Fei Chen
    • Asmamaw T Wassie
    • Edward S Boyden
    Research
    Nature Methods
    Volume: 13, P: 679-684

  • GPAT1 is a mitochondrial outer membrane protein that catalyzes the first step of glycerolipid biosynthesis. Cryo-EM structures and functional studies of human GPAT1 uncover the molecular architecture and mechanism of this important acyltransferase.

    • Zachary Lee Johnson
    • Mark Ammirati
    • Huixian Wu
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 22-30

  • Iterative expansion microscopy (iExM) is a strategy that achieves high resolution expansion microscopy by expanding samples multiple times. Expanding a sample twice enables ∼4.5 × 4.5 ∼20× physical expansion and ∼25 nm resolution.

    • Jae-Byum Chang
    • Fei Chen
    • Edward S Boyden
    Research
    Nature Methods
    Volume: 14, P: 593-599