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Showing 1–2 of 2 results
Advanced filters: Author: Shonit R. Das Clear advanced filters

  • Acute lung injury caused by inhalation of pathogens leads to mortality, but the mechanisms are unclear. Here, the authors show in mice that that loss of the mitochondrial calcium uniporter (MCU) of alveolar type 2 cells (AT2) impaired mitochondrial Ca2+ buffering and surfactant secretion, and increased mortality, in response to LPS instillation, suggesting the MCU as a potential therapeutic target in ALI.

    • Mohammad Naimul Islam
    • Galina A. Gusarova
    • Jahar Bhattacharya
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Bone-marrow–derived stromal cells are known to protect against acute lung injury. Jahar Bhattacharya and colleagues now show that one way these cells offer such protection is to transfer their mitochondria to the injured lung epithelia to improve the bioenergetics of the recipient cells, thus probably allowing them to recover from injury more efficiently.

    • Mohammad Naimul Islam
    • Shonit R Das
    • Jahar Bhattacharya
    Research
    Nature Medicine
    Volume: 18, P: 759-765