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Showing 1–6 of 6 results

Advanced filters: Author: Shouqing Sun Clear advanced filters

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

The autophagy protein p62 undergoes liquid-liquid phase separation but how this is regulated is unclear. Here, the authors report that the histone chaperone DAXX interacts with p62 in the cytoplasm to drive its phase separation.

Yi Yang
Thea L. Willis
Shouqing Luo
ResearchOpen Access21 Aug 2019
Nature Communications

Volume: 10, P: 1-18
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.

Zhaoyang Li
Cen Wang
Boxun Lu
Research30 Oct 2019
Nature

Volume: 575, P: 203-209
Overactive autophagy is a pathological mechanism underlying premature suture ossification in nonsyndromic craniosynostosis

Shanshan Qiu
Jing Wang
Nan Bao
ResearchOpen Access25 Apr 2018
Scientific Reports

Volume: 8, P: 1-8
Chronic olanzapine administration causes metabolic syndrome through inflammatory cytokines in rodent models of insulin resistance

Huqun Li
Shiyong Peng
Weiyong Li
ResearchOpen Access07 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Degradation of lipid droplets by chimeric autophagy-tethering compounds

Yuhua Fu
Ningxie Chen
Boxun Lu
ResearchOpen Access08 Jul 2021
Cell Research

Volume: 31, P: 965-979
Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

Jianchun Wu
Hai Jiang
Honglin Li
Research12 Mar 2013
Cell Research

Volume: 23, P: 691-704