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Showing 1–5 of 5 results
Advanced filters: Author: Shoval Miyara Clear advanced filters
  • A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

    • Shoval Miyara
    • Eldad Tzahor
    News & Views
    Nature Cardiovascular Research
    Volume: 4, P: 508-510
  • Sarig and Tzahor et al. show that the multiple sclerosis drug glatiramer acetate improves cardiac function and reduces scar area in rodent models of acute myocardial infarction and ischemic heart failure.

    • Gal Aviel
    • Jacob Elkahal
    • Rachel Sarig
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 1049-1066
  • Shakked et al. highlight the importance of cardiomyocytes’ redifferentiation after dedifferentiation and proliferation in cardiac repair and show that redifferentiation depends on negative feedback signaling and LATS1/2 Hippo pathway activity. Cardiomyocyte redifferentiation not only promotes the restoration of cardiac function but also protects against future insult.

    • Avraham Shakked
    • Zachary Petrover
    • Eldad Tzahor
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 383-398
  • Zhang et al. show that Egr1 regulates transient senescence during neonatal heart regeneration and upon agrin-mediated cardiac repair in adult mice, acting downstream of the integrin–FAK–ERK–Akt1 axis in cardiac fibroblasts.

    • Lingling Zhang
    • Jacob Elkahal
    • Eldad Tzahor
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 915-932
  • The tumor microenvironment (TME) is complex and heterogenous, with cancer cells and diverse non-malignant cells interacting with each other. Here the authors define the network of interactions between different cell types in the TME of breast cancer, identifying and characterizing a two-cell circuit of cancer associated fibroblasts and macrophages.

    • Shimrit Mayer
    • Tomer Milo
    • Ruth Scherz-Shouval
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17