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Showing 1–7 of 7 results
Advanced filters: Author: Shrey Sindhwani Clear advanced filters

  • Scientists have reacted to COVID-19 restrictions by organizing virtual seminars and journal clubs to maintain engagement. The authors reflect on their experiences and lessons learned from organizing such initiatives and highlight how, far from being temporary substitutes of in-person counterparts, they can help foster more diverse, inclusive and environmentally friendly scientific exchange.

    • James P. K. Armstrong
    • Irene de Lázaro
    • Shrey Sindhwani
    Comments & Opinion
    Nature Reviews Materials
    Volume: 6, P: 963-965

  • The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans-endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

    • Shrey Sindhwani
    • Abdullah Muhammad Syed
    • Warren C. W. Chan
    Research
    Nature Materials
    Volume: 19, P: 566-575

  • Tumour endothelial cell macropinocytosis is the dominant mechanism for nanoparticle entry into the tumour. Enhanced nanoparticle tumour accumulation may be due to upregulated macropinocytosis membrane ruffling compared with most healthy tissues.

    • Jamie L. Y. Wu
    • Qin Ji
    • Warren C. W. Chan
    Research
    Nature Nanotechnology
    Volume: 20, P: 672-682

  • Nanoparticle retention inside tumours has been associated with lymphatic vessel collapse. It is now shown that nanoparticles exit from solid tumours through lymphatic vessels in or surrounding the tumour by a nanoparticle-size-dependent mechanism.

    • Luan N. M. Nguyen
    • Zachary P. Lin
    • Warren C. W. Chan
    Research
    Nature Materials
    Volume: 22, P: 1261-1272

  • Depletion of tumour-associated platelets improves the delivery of anticancer drugs.

    • Abdullah Muhammad Syed
    • Shrey Sindhwani
    • Warren C. W. Chan
    News & Views
    Nature Biomedical Engineering
    Volume: 1, P: 629-631

  • The mechanisms of nanoparticle delivery to solid tumours guide the engineering of nanoparticles for cancer applications. This Review discusses two contrasting nanoparticle delivery mechanisms, the enhanced permeability and retention effect and the active transport and retention principle, and their implications for the design of cancer nanomedicines.

    • Luan N. M. Nguyen
    • Wayne Ngo
    • Warren C. W. Chan
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 201-213