The surface glycoprotein of the distinct ebolavirus responsible for the largest outbreak yet described (Sudan Gulu) has been crystallized in complex with a novel, neutralizing antibody. The crystal structure and accompanying in vitro and in vivo experiments demonstrate that the antibody functions after virus entry and illustrates a key hotspot for ebolavirus neutralization.
- João M Dias
- Ana I Kuehne
- Erica Ollmann Saphire