Trifluoromethyl diazomethane is a versatile reagent with a variety of applications. Here its 1,3-dipolar cycloaddition across internal and terminal alkynes is shown to provide an efficient route to trifluoromethyl-substituted pyrazoles, including derivatives of marketed drugs, natural products, and bioactive heterocycles.
- Shuaipeng Lv
- Hui Zhou
- Lei Wang
