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Showing 1–5 of 5 results
Advanced filters: Author: Shuhan Qin Clear advanced filters

  • While blue space has been linked to metabolic health, research has primarily focused on water quantity rather than quality. This study finds that lower water coverage and higher exposure to black-odorous water increase risk of metabolic syndrome.

    • Zhanpeng Wang
    • Yuanyuan Shi
    • Peng Jia
    Research
    Nature Water
    Volume: 4, P: 586-598

  • Standard algorithms fail to fully exploit the spatial information in DNA-PAINT. Here, the authors present G5M, an algorithm providing molecular maps by accurately inferring biomolecule positions at distances inaccessible to conventional analysis.

    • Rafal Kowalewski
    • Susanne C. M. Reinhardt
    • Ralf Jungmann
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • Targeting ribosome biogenesis with the ribosome inhibitor, homoharringtonine (HHT), is effective in leukaemia but not in solid tumours. Here, the authors demonstrate that in solid tumours, activation of JNK signaling following HHT-induced ribosomal stress promotes Snail1 accumulation in the nucleolus which facilitates ribosome biogenesis and resistance to HHT.

    • Kewei Qin
    • Shuhan Yu
    • Yong Yi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Aberrant EGFR activation is commonly found in non-small cell lung cancer (NSCLC). Here the authors show that E3 ubiquitin ligase FBXL2 targets EGFR and EGFR tyrosine kinase inhibitor (TKI)-resistant mutants for proteasome-mediated degradation to inhibit EGFR-driven NSCLC growth and TKI resistance.

    • Mengmeng Niu
    • Jing Xu
    • Zhi-Xiong Jim Xiao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15