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Showing 1–7 of 7 results

Advanced filters: Author: Shun Murayama Clear advanced filters

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex

The Rat1 RNase helps terminate eukaryotic mRNA transcription. Here, the authors report the cryo-EM structures of the Rat1-Rai1-Rtt103 and the Rat1-Rai1-RNAPII complexes, illustrating the mechanism of mRNA transcription termination.

Tatsuo Yanagisawa
Yuko Murayama
Shun-ichi Sekine
ResearchOpen Access08 Sept 2024
Nature Communications

Volume: 15, P: 1-12
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Long-term follow-up of belumosudil as second or subsequent line of therapy for steroid-dependent/resistant cGVHD: clinical outcomes from a Japanese study

Koji Kato
Yoshihiro Inamoto
Yoshinobu Maeda
CorrespondenceOpen Access26 Nov 2025
Bone Marrow Transplantation

P: 1-4
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein

A crystal structure of bacterial RNA polymerase (RNAP) bound to the transcription inhibitor Gfh1 reveals the mechanism of inhibition by Gfh1 and an alternative ratcheted state of RNAP.

Shunsuke Tagami
Shun-ichi Sekine
Shigeyuki Yokoyama
Research01 Dec 2010
Nature

Volume: 468, P: 978-982
A Japanese case of cerebellar ataxia, spastic paraparesis and deep sensory impairment associated with a novel homozygous TTC19 mutation

Misako Kunii
Hiroshi Doi
Fumiaki Tanaka
Research05 Feb 2015
Journal of Human Genetics

Volume: 60, P: 187-191
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14