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Showing 1–3 of 3 results
Advanced filters: Author: Shunming Fang Clear advanced filters

  • A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.

    • Leopold Kong
    • Kem A. Sochacki
    • Jenny E. Hinshaw
    Research
    Nature
    Volume: 560, P: 258-262

  • Mitochondria go through cycles of fusion and fission. The yeast dynamin-related protein, Dnm1, localizes to sites of membrane fission and fusion. Hinshaw and coworkers solve the structure of Dnm1-lipid tubes by cryo-EM and compare it to dynamin. Upon GTP addition, the Dnm1-lipid tubes constrict by ~50 nm, reducing the underlying lipid membrane. This suggests that Dnm1 has the ability to impart a large contractile force during mitochondrial division.

    • Jason A Mears
    • Laura L Lackner
    • Jenny E Hinshaw
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 20-26