The difluoromethoxy motif is valuable in pharmaceuticals and materials, yet direct difluoromethylation of complex alcohols remains challenging due to their high pKa and limited functional group compatibility of existing difluorocarbene sources. Here, the authors report a blue light- and acid-mediated difluoromethylation strategy, which repurposes Grushin’s reagent as an efficient difluorocarbene source.
- Shuolu Dai
- Chuhong Xie
- Yonggui Robin Chi
