SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models.
- Chen Xing
- Cong Zhang
- Yan Liu
