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  • Group A Streptococcus secretes a protease, SpeB, that directly cleaves and activates gasdermin A to induce pyroptosis of infected keratinocytes, demonstrating a role for gasdermin A in immune defence against invasive microorganisms.

    • Doris L. LaRock
    • Anders F. Johnson
    • Christopher N. LaRock
    Research
    Nature
    Volume: 605, P: 527-531