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Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.

Si Naftaly
Itay Cohen
Niv Papo

ResearchOpen Access26 Sept 2018

Nature Communications

Volume: 9, P: 1-10

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Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

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