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Showing 1–2 of 2 results
Advanced filters: Author: Si-Ru Zheng Clear advanced filters

  • Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

    • Tao-Tao Chen
    • Qiuhua Lu
    • Songying Ouyang
    Research
    Nature Chemical Biology
    Volume: 22, P: 152-162

  • The bacterial pathogen Legionella pneumophila secretes effectors that affect protein ubiquitination within host cells, involving production of phosphoribosyl ubiquitin (PR-Ub). Here, the authors identify additional effectors that convert PR-Ub back into functional ubiquitin, thus maintaining ubiquitin homeostasis in infected cells.

    • Jiaqi Fu
    • Siying Li
    • Zhao-Qing Luo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13