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Showing 1–2 of 2 results
Advanced filters: Author: Siavash Vahidi Clear advanced filters

  • Mabanglo, Leung, Vahidi, Seraphim et al. examine the structural changes to ClpP from Neisseria meningitidis and Escherichia coli upon binding to two novel activators. They show that reorganization of the electrostatic interaction networks at the ClpP entrance pores is needed for activation.

    • Mark F. Mabanglo
    • Elisa Leung
    • Walid A. Houry
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-14

  • Despite the implied allosteric modulation of the M. tuberculosis 20S core particle (CP), the specific conformations involved remained elusive. Here, the authors use cryo-EM and HDX-MS to determine the 20S CP structure in an auto-inhibited state that is distinguished from the canonical resting state.

    • Madison Turner
    • Adwaith B. Uday
    • Siavash Vahidi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16