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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

The apelin receptor regulates heart and metabolic health via G-protein and β-arrestin signaling pathways. Here, authors present receptor-β-arrestin complex structures with distinct stoichiometries that provide insight into biased signaling, guiding targeted drug design.

Yang Yue
Chanjuan Xu
Fei Xu
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-12

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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

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