Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with poor prognosis and limited treatment options. This study identifies Prolyl 3- hydroxylase 1 (P3H1) as a critical regulator of PDAC progression through PLK1-β-catenin signaling, driving tumor-associated macrophage recruitment and tumor growth.
- Panzhu Bai
- Chengmin Liu
- Ying Sun
