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Showing 1–3 of 3 results
Advanced filters: Author: Sidonie Wicky John Clear advanced filters

  • Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subsequent rupture, promoting cytotoxicity.

    • Laura Ramos Garcia
    • Tencho Tenev
    • Pascal Meier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.

    • Mariam H. Orme
    • Gianmaria Liccardi
    • Pascal Meier
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.

    • Rachael Barry
    • Sidonie Wicky John
    • Pascal Meier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14