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Showing 1–9 of 9 results
Advanced filters: Author: Sierin Lim Clear advanced filters

  • Formed by the self-assembly of protein subunits, protein nanocages can be engineered at the interior, exterior, and inter-subunit locations. Each type of modification can be tuned for specific biological applications. Multiple-modifications can be imparted to these nanocages without compromising its self-assembling property, creating multi-functional protein nanocage platforms. Potential applications of the modified protein nanocages include targeted delivery in complex cellular environments for therapeutic and diagnostic agents as well as modulation of cellular responses.

    • Sathyamoorthy Bhaskar
    • Sierin Lim
    ReviewsOpen Access
    NPG Asia Materials
    Volume: 9, P: e371

  • Synthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein synthesis.

    • Luis E. Contreras-Llano
    • Conary Meyer
    • Cheemeng Tan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Microbes have been shown to be effective for synthesizing functional materials. Here, bacterial cellulose is created via a dual microbial approach, with magnetite nanoparticles used to enhance magnetic behavior.

    • Sundaravadanam Vishnu Vadanan
    • Rupali Reddy Pasula
    • Sierin Lim
    ResearchOpen Access
    Communications Materials
    Volume: 5, P: 1-9

  • Illustration of cellular fate and responses of macrophages to ferritin NPs. With potential theranostic applications of organic NPs targeting macrophages, in-depth study of internalization and cellular responses of a model organic NP (Archaeoglobus fulgidus derived ferritin) is carried out. Multiple pathways for ferritin NP internalization are observed resulting in endosomal/lysosomal localization and intracellular Fe accumulation. Upregulation of endogenous ferritin and iron export protein are noted in response to lysosomal ferritin degradation and release of free Fe ions. Iron-dependent impacts on physiological immune markers and ROS are measured.

    • Samyukta Ravishankar
    • Anu Maashaa Nedumaran
    • Sierin Lim
    ResearchOpen Access
    NPG Asia Materials
    Volume: 15, P: 1-16

  • Using functionalized particles for treatment of cancer is advantageous because they can access remote parts of the body and is minimally invasive. However, current chemical and biological methods still face challenges. A novel approach that uses the physical force of stimuli-responsive hydrogels is introduced. Temperature-responsive hydrogels were coated with cell-adherent molecules. After attaching cancer cells on its surface and changing the temperature, the force of the expanding stimuli-responsive hydrogel ruptures the cells. Comparing to other chemical and biological methods, this physical approach may be conceptually simpler, technically easier to implement, and more general for different types of cancer cells.

    • Yan Fang
    • Jiajun Tan
    • Siowling Soh
    ResearchOpen Access
    NPG Asia Materials
    Volume: 10, P: e465

  • Bacterial cellulose (BC) has been utilized as a biopolymer matrix for various applications. The advancement of synthetic biology has brought new approaches for its production and functionalization. In this mini-review, we briefly discuss the conventional methods employed to improve BC production and functionalization as well as their challenges. We summarize the applications of synthetic biology to address the challenges and its use to develop novel hybrid living materials. Finally, we consider the opportunities and future prospects of synthetic biology and engineered biological materials.

    • Sundaravadanam Vishnu Vadanan
    • Anindya Basu
    • Sierin Lim
    Reviews
    Polymer Journal
    Volume: 54, P: 481-492