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Mosquito salivary sialokinin reduces monocyte activation and chikungunya virus-induced inflammation via neurokinin receptors

The role of mosquito saliva proteins in viral infection remains incompletely understood. Here, the authors show that sialokinin facilitates viral dissemination while suppressing immune response and inflammation in chikungunya virus-infected mice.

Siew-Wai Fong
Jeslin J. L. Tan
Lisa F. P. Ng
ResearchOpen Access20 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development.

Chek Meng Poh
Guillaume Carissimo
Lisa F. P. Ng
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-7
Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose of vaccine can improve these antibody levels.

Laurent Renia
Yun Shan Goh
Lisa F. P. Ng
ResearchOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

Yun Shan Goh
Siew-Wai Fong
Laurent Renia
ResearchOpen Access07 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

Single cell transcriptomics can reveal at high resolution the body’s response to infection. Here the authors have applied this technology to a longitudinal SARS-CoV-2 infected cohort and identified gene expression changes that may predict disease severity and reveal the underlying molecular mechanisms.

Quy Xiao Xuan Lin
Deepa Rajagopalan
Shyam Prabhakar
ResearchOpen Access18 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.

Guillaume Carissimo
Weili Xu
Lisa FP Ng
ResearchOpen Access16 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Efficient RNA drug delivery using red blood cell extracellular vesicles

RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.

Waqas Muhammad Usman
Tin Chanh Pham
Minh T. N. Le
ResearchOpen Access15 Jun 2018
Nature Communications

Volume: 9, P: 1-15
Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma

Teo et al. study neutrophil activity and endothelial glycocalyx damage in plasma collected from healthy individuals and patients with severe and non-severe COVID-19. They show that neutrophil myeloperoxidase activity and endothelial glycocalyx proteins increase with disease severity, and remain high despite clinical recovery.

Andrew Teo
Louisa L. Y. Chan
Tsin Wen Yeo
ResearchOpen Access05 May 2023
Communications Medicine

Volume: 3, P: 1-9
Author Correction: Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

Yun Shan Goh
Siew-Wai Fong
Laurent Renia
Amendments and CorrectionsOpen Access17 Jan 2024
Scientific Reports

Volume: 14, P: 1-2
Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

Bei Wang
Yun Shan Goh
Cheng-I Wang
ResearchOpen Access25 Oct 2021
npj Vaccines

Volume: 6, P: 1-9
Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

Yue Gu
Bhuvaneshwari Shunmuganathan
Paul A. MacAry
ResearchOpen Access09 Dec 2023
Scientific Reports

Volume: 13, P: 1-14

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