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Showing 1–2 of 2 results
Advanced filters: Author: Siew-Siew Pang Clear advanced filters

  • The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.

    • Bradley A. Spicer
    • Ruby H. P. Law
    • Michelle A. Dunstone
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • The pre-T-cell antigen receptor mediates early T-cell development and differentiation. These authors report its structure and explain how the head-to-tail dimeric arrangement allows the interaction of the pre-Tα domain with any variable β domain, and provides the basis for ligand-independent signalling.

    • Siew Siew Pang
    • Richard Berry
    • Jamie Rossjohn
    Research
    Nature
    Volume: 467, P: 844-848