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Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL

The molecular mechanisms underlying resistance to therapy in Chronic lymphocytic leukemia (CLL) remain to be explored. Here, the authors perform multi-omics analysis in a mouse model of ibrutinib resistance and suggest proteasome inhibition for overcoming it.

Lavinia Arseni
Gianluca Sigismondo
Martina Seiffert
ResearchOpen Access26 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Unchanged frequency of moraine-dammed glacial lake outburst floods in the Himalaya

Melting glaciers are increasing Himalayan glacial lakes and potentially the risk of outburst floods. An advanced automated algorithm identifies glacial lake outburst floods from Landsat images since the late 1980s to improve understanding of these events and trends in their frequency.

Georg Veh
Oliver Korup
Ariane Walz
Research18 Mar 2019
Nature Climate Change

Volume: 9, P: 379-383
Interrelations of vegetation growth and water scarcity in Iran revealed by satellite time series

Robert Behling
Sigrid Roessner
Christof Lorenz
ResearchOpen Access01 Dec 2022
Scientific Reports

Volume: 12, P: 1-22

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