Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Sigurd Braun Clear advanced filters

  • The Braun lab shows that the conserved nuclear membrane protein Lem2 interacts with the MTREC complex of the nuclear-exosome pathway to promote recruitment and degradation of ncRNAs and meiotic transcripts at the nuclear periphery in Schizosaccharomyces pombe.

    • Lucía Martín Caballero
    • Matías Capella
    • Sigurd Braun
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 910-921

  • rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering complex facilitate the nucleolar release of damaged repeats to maintain genome integrity.

    • Matías Capella
    • Imke K. Mandemaker
    • Sigurd Braun
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Telomeres and centromeres are specialized chromosomal regions with distinct functions. Here, the authors uncover a long-distance molecular communication between these key regions, coordinating the formation of the telomere bouquet and the initiation of the meiotic program.

    • Alberto Jiménez-Martín
    • Alberto Pineda-Santaella
    • Alfonso Fernández-Álvarez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Flow cytometry is often hindered by undesired fluctuations in fluorescence intensity. Here, the authors propose high-throughput fluorescence lifetime imaging flow cytometry, which enables imaging at a rate of over 10,000 cells per second and, therefore, enhances the capabilities of cellular analysis.

    • Hiroshi Kanno
    • Kotaro Hiramatsu
    • Keisuke Goda
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Protein abundance is controlled at the transcriptional, translational and posttranslational levels. Here, Öztürk et al. determine proteome changes resulting from individual knockout of 3308 nonessential genes in the yeast S. pombe, infer gene functionality, and show that protein upregulation under stable transcript expression utilizes optimal codons.

    • Merve Öztürk
    • Anja Freiwald
    • Falk Butter
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Epigenetic memory of silent chromatin often requires robust feedback loops between factors processing small non-coding RNAs and enzymes involved in heterochromatin assembly. A study published in Molecular Cell now demonstrates that these feedback loops can persist in a phenotypically neutral state even when gene expression is reactivated, and that they maintain the potential to reinstall heterochromatin in later generations when conditions change.

    • Matías Capella
    • Sigurd Braun
    News & Views
    Nature Structural & Molecular Biology
    Volume: 26, P: 391-392

  • To increase the range and precision of genetic interaction studies in Saccharomyces cerevisiae, a collection of hypomorphic alleles of essential yeast genes and a highly sensitive flow cytometry–based growth competition assay are presented. Also in this issue, Yan et al. present a similar strain collection, tagged with unique bar-code identifiers, and use this collection in pooled chemical genetic screens.

    • David K Breslow
    • Dale M Cameron
    • Jonathan S Weissman
    Research
    Nature Methods
    Volume: 5, P: 711-718

  • Pflügler, Svinka et al. identify a subset of Paneth cells in mouse intestinal crypts and tumors, which express the immune checkpoint molecule Ido1 in a Stat1-dependent manner and promote tumor growth. Gene expression data from human colorectal cancer (CRC) suggest that a similar population is present in human cancer and opens the door for further studies of immune escape mechanisms in CRC.

    • Sandra Pflügler
    • Jasmin Svinka
    • Robert Eferl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14