Here authors generate a glycoengineered keratinocyte library delineating human glycosylation pathways. The use of this library reveals that each stage of the HSV-1 infectious cycle is sensitive to alterations in the cellular glycan landscape, identifying critical biosynthetic steps that could be exploited for targeting HSV-1.
- Ieva Bagdonaite
- Irina N. Marinova
- Hans H. Wandall