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  • The structure of human ATP-citrate lyase, in complex with a newly developed small-molecule inhibitor, shows extensive conformational changes that reveal an allosteric site for the inhibitor to bind and indirectly compete with the citrate substrate.

    • Jia Wei
    • Silvana Leit
    • Liang Tong
    Research
    Nature
    Volume: 568, P: 566-570